Effect of 1050 mg fluphenazine decanoate given intramuscularly over six days.
نویسندگان
چکیده
منابع مشابه
Fluphenazine Decanoate in Chronic Schizophrenia
Introduction of chlorpromazine by Delay and Danikcr in 1952 revolutionized the treatment of acute schizophrenia. However, chronic form of the illness still remains a challenge, mainly because of noncompliance of the patients with the therapeutic regimen (Diamond and Marks, 1960; Olson and Peterson, 1960; Hare and Willcox, 1967 ; Wilson and Enoch, 1967 and Ayd, 1975). Another factor is the errat...
متن کاملQuantitation of fluphenazine in equine serum following fluphenazine decanoate administration.
Fluphenazine, a potent antipsychotic used to treat schizophrenia in humans, is used in racehorses as a performance-enhancing drug, and for that reason it has been banned by the Association of Racing Commissioners International. A liquid chromatography-tandem mass spectrometry method for detecting and quantitating fluphenazine in equine serum was developed and validated. The method was then empl...
متن کاملEmergence of apomorphine-induced 'vacuous chewing' during 6 months continuous treatment with fluphenazine decanoate.
The treatment of animals with neuroleptic drugs for periods of a few results in the induction of dopamine (DA) receptor supersensitivity that is reflected, on drugwithdrawal, by enhanced behavioural responses to DA agonist drugs (Muller and Seeman, 1978). Such phenomena have been considered to exemplify the pathophysiology of tardive dyskinesia (Baldessarini and Tarsy, 1980) despite the require...
متن کاملSensitive method for the simultaneous measurement of fluphenazine decanoate and fluphenazine in plasma by high-performance liquid chromatography with coulometric detection.
A highly sensitive and specific high-performance liquid chromatographic method with coulometric detection was developed for the simultaneous assay of fluphenazine decanoate and fluphenazine in plasma. The extraction and sample clean-up procedures are simple, rapid to execute, yet yield chromatograms relatively free of any interference from endogenous plasma constituents, such that the extraordi...
متن کاملProlactin levels and amphetamine-induced behavioural changes following fluphenazine decanoate administration.
A single injection of fluphenazine decanoate (FD) antagonized effects of acute d-amphetamine (2.5 mg/kg) for a variable period of time (4 to 28 days), depending upon the dosage of the neurolcptic used (2.5 or 5.0 mg/kg) and the behavioural parameter(s) monitored. Locomotion and rearing were antagonized for a longer duration than was sniffing. Normal locomotor response to amphetamine was attaine...
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ژورنال
عنوان ژورنال: BMJ
سال: 1983
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.286.6370.1016